Medical Applications of Finite Mixture Models

Overview over the Book.- - Heterogeneity in Medicine.- Modeling Count Data.- Theory and Algorithms.- Disease Mapping and Cluster Investigations.- Modeling Heterogeneity in Psychophysiology.- Investigating and Analyzing Heterogeneity in Meta-Analysis.- Analysis of Gene Expression Data.

From the reviews:

"This book is intended as a resource for working statisticians, epidemiologists, pharmacokineticists and physicians. ... the material is most suitable for working (bio)statisticians who wish to apply finite mixture models. The book would make a good supplementary textbook for say a second year master's level course. ... there are many nice examples demonstrating finite mixture modeling. ... Each example is extremely well motivated. ... Overall, the book is well written ... ." (Timothy D. Johnson, Journal of the American Statistical Association, Vol. 106 (493), March, 2011)

"This lucid and consistent presentation should be welcome by researchers in the greater domain of biomedical research. This impressive monograph attempts to cover the use of finite mixture models in a variety of biomedical problems, illustrated by appropriate case studies. ... Statistical analysis has been presented consistently at an intermediate level so that researchers in a broader biomedical field, constituting the general audience of this book, can appreciate the rationality of statistical modelling and analysis to a greater extent." (Pranab K. Sen, International Statistical Review, Vol. 79 (2), 2011)

"The motivation for this book is that the features of medical data can be governed by the existence of several groups/clusters/classes. ... Through detailed examples and theoretical background, the book is successful in showing how finite mixtures and related methods can be applied in medical contexts. ... this is a very interesting and generally well-written book. ... it should be of interest to readers from the physical and engineering sciences because finite mixture analysis is widely applicable." (Charles Heckler, Technometrics, Vol. 52 (4), November, 2010)