Post-Traumatic Stress Disorder (eBook)
XIII, 418 Seiten
Humana Press (Verlag)
978-1-60327-329-9 (ISBN)
Post-traumatic stress disorder is a psychiatric illness that can occur in anyone who has experienced a life-threatening or violent event. The trauma can be due to war, terrorism, torture, natural disasters, violence, or rape. In PTSD the brain areas that are likely to be affected are the hippocampus (memory), amygdala (fear association), the prefrontal cortex (cognitive processing), and the ascending reticular activating system (arousal). The chemical of interest is norepinephrine, which is released during a stressful event and is part of the fight-or-flight response meant to mobilize the body to action.The objective of this title is to outline the neurobiology of post-traumatic stress disorder and provide treatment strategies for clinicians. The chapter material from this book has evolved from a seminar on PTSD held recently under the auspices of the VA Boston Healthcare System, Boston University Medical Center and Harvard Medical School. We propose a book that will focus on the epidemiology, neurobiology, MRI studies, animal models, arousal and sleep issues, clinical trials, and treatment strategies for clinicians. Treatment will cover such topics as guidelines for treating posttraumatic stress disorder, PTSD and the use of mental health services, cognitive intervention therapy, and large scale clinical trials in PTSD. This collection will be a vital source of information to clinicians and neuroscientists.
Post-traumatic stress disorder is a psychiatric illness that can occur in anyone who has experienced a life-threatening or violent event. The trauma can be due to war, terrorism, torture, natural disasters, violence, or rape. In PTSD the brain areas that are likely to be affected are the hippocampus (memory), amygdala (fear association), the prefrontal cortex (cognitive processing), and the ascending reticular activating system (arousal). The chemical of interest is norepinephrine, which is released during a stressful event and is part of the fight-or-flight response meant to mobilize the body to action.The objective of this title is to outline the neurobiology of post-traumatic stress disorder and provide treatment strategies for clinicians. The chapter material from this book has evolved from a seminar on PTSD held recently under the auspices of the VA Boston Healthcare System, Boston University Medical Center and Harvard Medical School. We propose a book that will focus on the epidemiology, neurobiology, MRI studies, animal models, arousal and sleep issues, clinical trials, and treatment strategies for clinicians. Treatment will cover such topics as guidelines for treating posttraumatic stress disorder, PTSD and the use of mental health services, cognitive intervention therapy, and large scale clinical trials in PTSD. This collection will be a vital source of information to clinicians and neuroscientists.
Preface 5
About the Editors 7
Contents 9
Contributors 11
Post-Traumatic Stress Disorder: Definition, Prevalence, and Risk Factors 14
Amygdala and Fear 33
The Amygdala and the Neural Pathways of Fear 34
Physiology of the Amygdala: Implications for PTSD 50
Counteracting Molecular Pathways Regulating the Reduction of Fear: Implications for the Treatment of Anxiety Diseases 90
Memory in PTSD: A Neurocognitive Approach 115
Animal Models of Post-Traumatic Stress Disorder 141
Toward Animal Models of Post- Traumatic Stress Disorder 142
PTSD: From Neurons to Networks 159
Post-Traumatic Stress Disorder and Arousal 193
Arousal Neurons in the Brain 194
Hyperarousal and Post- Traumatic Stress Disorder: A Role for the Hypocretin System 208
The Locus Coeruleus-Noradrenergic System and Stress: Implications for Post- Traumatic Stress Disorder 219
Effect of Stress on Sleep and Its Relationship to Post- Traumatic Stress Disorder 237
Stress Hormones in Post-Traumatic Stress Disorder 260
Stress Hormones and PTSD 261
Low Basal Cortisol and Startle Responding as Possible Biomarkersof PTSD: The Influence of Internalizing and Externalizing Comorbidity 280
Brain Imaging in Post-Traumatic Stress Disorder 297
Functional Neuroimaging in Post- Traumatic Stress Disorder 298
The Amygdala in Post-Traumatic Stress Disorder 319
Treatment Strategies 335
Pharmacologic Treatment of PTSD 336
Guided Imagery as a Therapeutic Tool in Post- Traumatic Stress Disorder 361
Virtual Reality Exposure Therapy for Combat- Related PTSD 373
Index 398
Color Plates 407
Erscheint lt. Verlag | 6.3.2009 |
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Zusatzinfo | XIII, 418 p. |
Verlagsort | Totowa |
Sprache | englisch |
Themenwelt | Geisteswissenschaften ► Psychologie |
Medizin / Pharmazie ► Allgemeines / Lexika | |
Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie | |
Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie | |
Schlagworte | Cortex • Flashbacks • Hyperaroused • Hypervigilance • Intervention • Neurobiology • neurons • Nightmares • Physiology • Post-traumatic stress disorder • PTSD • Stress • therapy • Trauma |
ISBN-10 | 1-60327-329-8 / 1603273298 |
ISBN-13 | 978-1-60327-329-9 / 9781603273299 |
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