Molecular Testing in Cancer

George M. Yousef, MD, PhD University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada Serge Jothy, MD, PhD University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada

Part 1: Molecular approaches and techniques

 

Chapter 1: Transitioning Diagnostic Molecular Pathology to the Genomic Era: Cancer Somatic Mutation Panel Testing

Kitchener D. Wilson and Iris Schrijver

 

Chapter 2: Conventional and Molecular Cytogenetics in Cancer

Michelle Dolan

 

Chapter 3: Comparative Genomic Hybridization and Array based CGH in Cancer

Roland Hubaux, Victor D. Martinez, David Rowbotham, and Wan L. Lam

 

Chapter 4: Polymerase Chain Reaction

Maria Pasic, Carlo Hojilia, and George M. Yousef

 

Chapter 5: Single Nucleotide Polymorphisms (SNPs)

Jyotsna Batra, Srilakshmi Srinivasan, and Judith Clements

 

Chapter 6: Clinical Application of DNA Sequencing: Sanger and Next-Generation Platforms

John D. McPherson

 

Chapter 7: Microarray-based Investigations in Cancer

Maud H.W. Starmans, Syed Haider, Cindy Yao, Philippe Lambin, and Paul C. Boutros

 

Chapter 8: Proteomics in Cancer Diagnostics

Kevin P. Conlon, Delphine Rolland, Kojo S. J. Elenitoba-Johnson

 

Chapter 9: Circulating Tumor Cells: A Non-Invasive Liquid Biopsy in Cancer

Evi S. Lianidou

 

Part 2: Molecular applications in various malignancies

 

Chapter 10: Molecular Testing in Hematological Malignancies

Amir Behdad, Bryan L. Betz, Megan S. Lim, and Nathanael G. Bailey

 

Chapter 11: Molecular Testing in Breast Cancer

Dimitrios Zardavas, Debora Fumagalli, and Christos Sotiriou

 

Chapter 12: Molecular Pathology of Gastrointestinal Tumors

Andrea Grin and Serge Jothy

 

Chapter 13: Molecular Testing in Pulmonary Tumors

Jeffrey J. Tanguay, Shirin Karimi, David M. Hwang, and Ming-Sound Tsao

 Chapter 14: Molecular testing in Gynecological Malignancies

Pamela M. Ward and Louis Dubeau

 

Chapter 15: Molecular Testing in Central Nervous System tumors

Jason Karamchandani

 

Chapter 16: Molecular Testing in Adult Kidney Tumors

Manal Y. Gabril and George M. Yousef

 

Chapter 17: Molecular Testing in Prostate Cancer

Manal Y Gabril and George M Yousef

 

Chapter 18: Molecular Testing in Urothelial Tumors

Manal Y Gabril and George M Yousef

 

Chapter 19: Molecular Testing in Thyroid Cancer

Matthew T. Olson, Jason D. Prescott, and Martha A. Zeiger

 

CHapter 20: Molecular Testing of Head and Neck Tumors

Diana Bell and Ehab Y. Hanna

 

Chapter 21: Molecular Testing in Bone and Soft Tissue Tumors

Brendan C. Dickson, Gino R. Somers, Rita A. Kandel 

Chapter 22: Molecular testing in Cutaneous Melanoma  

Margaret Redpath, Leon van Kempen, Caroline Robert, and Alan Spatz

 

Chapter 23: Molecular Testing in Pediatric Tumors

Gino R. Somers and Paul S. Thorner

 

Chapter 24: Pharmacogenomics in Molecular Oncology

Gregory J. Tsongalis

 

Chapter 25: Quality Assurance in Molecular Testing of Cancer

Sylviane Olschwang, Simon Patton, Etienne Rouleau, and Elisabeth Dequeker