Fluorescence Imaging for Surgeons

Fernando Dip, MD, MAACThe Bariatric and Metabolic InstituteSection of Minimally Invasive SurgeryDepartment of General and Vascular SurgeryCleveland Clinic FloridaWeston, FL  USAAndOncological Surgical Division, Department of SurgeryDivision of Surgical ResearchHospital de Clinicas Buenos AiresUniversity of Buenos AiresBuenos Aires, ArgentinaTakeaki Ishizawa, MD, PhD, FACSDepartment of Gastroenterological Surgery, Cancer Institute Hospital Japanese Foundation for Cancer Reserach Koto-ku, Tokyo JapanAndHepato-Biliary-Pancreatic Surgery Division, Department of SurgeryGraduate School of Medicine, The University of TokyoBunkyo-ky, TokyaJapanNorihiro Kokudo, MD, PhD, FACSProfessor and ChairmanHepato-Biliary-Pancreatic Surgery Division, Department of SurgeryGraduate School of Medicine, The University of TokyoBunkyo-ky, TokyaJapanRaul J. Rosenthal, MD, FACSChief of StaffThe Bariatric & Metabolic InstituteSection of Minimally Invasive Surgery Department of General & Vascular Surgery Cleveland Clinic Florida Weston, FL USA

lt;p>Section I: Background

Chapter 1

Basic Concepts of Fluorescence and Fluorescent Probes

Guillermo O. Menéndez, Federico Coluccio Leskow, and Carla C. Spagnuolo

Chapter 2

Past, Present and Future of Fluorescence

Daniel Debonis, Pablo Quadri, Manuel Montesinos, Jorge Falco, David Nguyen, Diego Sinagra, Fernando Dip, and Raul J. Rosenthal

Chapter 3

Translation of Therapeutic Antibodies for Intraoperative Fluorescence Imaging

Eben L. Rosenthal and Jason M. Warram

Chapter 4

Review of Indocyanine Green Imaging in Surgery

Jarmo T. Alander, Outi M. Villet, Tommi Pätilä^, Ilkka S. Kaartinen, Martin Lehecka, Toshiya Nakaguchi, Taku Suzuki^, and Valery Tuchin

Section II: Imaging Systems

Chapter 5

D-Light P System (Karl Storz) (with video)

Rutger M. Schols, Nicole D. Bouvy, Ronald M. van Dam, Laurents P.S. Stassen,

Chapter 6

Robotic surgery using Firefly System

Giuseppe Spinoglio, Alessandra Marano, Giampaolo Formisano

Chapter 7

Fluorescence imaging systems (PDE, HyperEye Medical System, and prototypes in Japan)

Takeaki Ishizawa and Norihiro Kokudo

Chapter 8

The Pinpoint System
Jana L. Lewis and Danny A. Sherwinter

Chapter 9

Economic Impact of Fluorescent Cholangiography

Emanuele Lo Menzo, Fernando Dip, Samuel Szomstein, and Raul J. Rosenthal

Chapter 10

Real-time near-infrared fluorescent cholangiography during robotic single-site cholecystectomy

Nicolas C. Buchs

Chapter 11

Fluorescent guided liver surgery: Paul Brousse experiences and perspective

Mohamed Bekheit and Eric Vibert

Chapter 12

Fluorescence imaging in laparoscopic hepatectomy (with video)

Yoshikuni Kawaguchi, Takeo Nomi, David Fuks, Norihiro Kokudo, and Brice Gayet

Section III. Clinical Applications of Intraoperative Fluorescence Imaging

Chapter 13

Identification of hepatic segment (with video)

Masaki Ueno

Chapter 14

Intraoperative evaluation of regional portal uptake function (with video)

Yoshikuni Kawaguchi, Takeaki Ishizawa, and Norihiro Kokudo

Chapter 15

Identification of hepatocellular carcinoma (with video)

Yoshifumi Morita, Takanori Sakaguchi, Hirotoshi Kikuchi, Naoki Unno, and Hiroyuki Konno

Chapter 16

Identification of metastatic liver cancer (with video)

Henricus J.M. Handgraaf, Floris P.R. Verbeek, Cornelis J.H. van de Velde, Merlijn Hutteman, and Alexander L. Vahrmeijer

Chapter 17

Prediction for postoperative intrahepatic recurrence of hepatocellular carcinoma
Kunihito Gotoh, Shigeru Marubashi, Terumasa Yamada, Hirofumi Akita, Hidenori Takahashi, Masahiko Yano, Osamu Ishikawa, Masato Sakon

Chapter 18

Detection of bile leakage after hepatic resection by intraoperative indocyanine green fluorescent imaging

Masaki Kaibori, Kosuke Matsui, Morihiko Ishizaki, Masanori Kwon

Chapter 19

Near-infrared laser photodynamic therapy for human hepatocellular carcinoma cell line tumor with indocyanine green fluorescence

Junichi Kaneko, Yoshinori Inagaki, Takeaki Ishizawa, Norihiro Kokudo

Chapter 20

Photodynamic diagnosis of gastric cancer using 5-aminolevulinic acid (with video)

Tsutomu Namikawa, Keiji Inoue, Taro Shuin, and Kazuhiro Hanazaki

Chapter 21

Applications of ICG Fluorescence Imaging for Surgery in Colorectal cancer

Shingo Shimada, Seiji Ohtsubo, and Mitsuo Kusano

Chapter 22

Fluorophore-conjugated chimeric anti-CEA antibodies for fluorescence-guided surgery of gastrointestinal (GI) tumors

Michael Bouvet and Robert M. Hoffman

Chapter 23

Development of a non-blurring, dual-imaging (X-ray/fluorescence) tissue marker for localization of gastrointestinal tumors

Hideki Hayashi, Taro Toyota, Shoichi Goto, Aki Oishi, Tao Gao, Lau Bik Ee, Hisahiro Matsubara

Chapter 24

Sentinel Node Navigation Surgery by Infrared Imaging in Gastric Cancer

Yoshikazu Uenosono, MD, Takaaki Arigami, Shigehiro Yanagita, Daisuke Matsushita, Sumiya Ishigami, and Shoji Natsugoe

Chapter 25

A dual infrared ray imaging system for sentinel node mapping against early gastric cancer: absorption and florescence methods by infrared ray electronic endoscopy combined with indocyanine green

Naoto Takahashi, Hiroshi Nimura, Muneharu Fujisaki, Norio Mitsumori, and Katsuhiko Yanaga

Chapter 26

Indocyanine green fluorescence-navigated sentinel node biopsy showed higher sensitivity than the conventional radioisotope or blue dye methods: it may help to reduce false-negative sentinel lymph node biopsies in skin cancer

Yasuhiro Fujisawa

Chapter 27

The indocyanine green method is equivalent to the (99m)Tc-labeled radiotracer method for identifying the sentinel node in breast cancer: A concordance and validation study

Bettina Ballardini, Germana Lissidini, and Paolo Veronesi

Chapter 28

Photodynamic detection of lymph node metastases in gastrointestinal cancer by using 5-aminolevulinic acid

Takeo Minamikawa, Yoshinori Harada, and Tetsuro Takamatsu

Chapter 29

Application of photodynamic treatment (with video)

Tomás G. Núñez and Tamara Portas

Chapter 30

Photodynamic diagnosis mediated by 5-aminolevulinic acid for urinary bladder cancer (with video)

Keiji Inoue, Hideo Fukuhara, and Taro Shuin

Chapter 31

Real-time assessment of intestinal perfusion by fluorescence-based enhanced reality

Michele Diana, Vincent Agnus and Jacques Marescaux

Chapter 32

Fluorescent angiography for flap planning and monitoring in reconstructive surgery

Georges Bettega, Clotilde Ochala, Marine Hitier, Cynthia Hamou¸ Stéphanie Guillermet, Pascal Gayet, and Jean-Luc Coll

Chapter 33

Fluorescein-Detection of Myocardial Ischemia in an Experimental Model of Acute Coronary Occlusion
Fernando Dip, Alejandro Damonte, Gaston Quiche, Marcelo Damonte, Fernando M. Safdie, Nicolas Brozzi, and Raul J. Rosenthal

Chapter 34

Spatial and Temporal Monitoring of Perfusion with Indocyanine Green Videoangiography in Rat Heart

Outi M. Villet, Jarmo T. Alander, and Ari L. Harjula

Chapter 35

Ureter identification using methylene blue and fluorescein

Fernando Dip, Alejandro Daniel Moreira Grecco, David Nguyen, Luis Sarotto, Sandy Perrins, and Raul J. Rosenthal

Chapter 36

Chymotrypsin probe for real-time visualization of pancreatic leak
Suguru Yamashita, Takeaki Ishizawa, Masayo Sakabe, Mako Kamiya, Yasuteru Urano, and Norihiro Kokudo