Hematologic Abnormalities and Acute Lung Syndromes

Janet S. Lee Associate Professor of Medicine Division of Pulmonary, Allergy, Critical Care Medicine University of Pittsburgh Pittsburgh, PA 15213

Part I: Overview.- The Lung-Blood Interface.- Leukocyte Kinetics and Migration in the Lungs.- Part II: Acute Pulmonary Manifestations Arising from Primary Hematologic Disorders.- Sickle Cell and Acute Chest Syndrome: Mechanisms and Pathogenesis.- Sickle Cell Disease and Acute Chest Syndrome: Epidemiology, Diagnosis, Management, Outcomes.- Thrombophilias and Acute Pulmonary Thromboembolic Disease.- Bleeding Disorders: Diagnosis and Treatment of Hemorrhagic Complications in the Intensive Care Unit.- Acute Pulmonary Manifestations of Hematologic Malignancies.- Acute Pulmonary Complications of Bone Marrow and Stem Cell Transplantation.- Part III: Transfusion-Related Complications.- Storage Lesion: Evolving Concepts and Controversies.- Transfusion and Acute Respiratory Distress Syndrome: Pathogenesis and Potential Mechanisms.- Transfusion and Acute Respiratory Distress Syndrome: Clinical Epidemiology, Diagnosis, Management, and Outcomes.- Transfusion Associated Circulatory Overload.- Transfusion-Related Immunomodulation (TRIM): From Renal Allograft Survival to Postoperative Mortality in Cardiac Surgery.

"This monograph is devoted to the presentation of pulmonary manifestations of hematologic disorders. ... Senior critical care trainees, pulmonologists, intensivists, and hematologists are an appropriate audience. ... This book brings a unique and effective combination of pulmonary and hematology expertise to bear on pulmonary manifestations of blood disorders. Chapters are brief, detailed and readable. Medical intensivists, in particular, will find this work helpful." (David J. Dries, Doody's Book Reviews, April, 2017)