Pseudo-Peptides in Drug Discovery

Peter E. Nielsen has been affiliated with the University of Copenhagen (Denmark) since 1980, and he became full professor at the Department of Medical Biochemistry and Genetics in 1995. He is one of the inventors of peptide nucleic acid (1991), and has further studied and developed this DNA mimic during the last 12 years. In 1998 he co-founded Pantheco A/S (now Santaris A/S), a small biotech company based in Denmark. Peter Nielsen is the co-author of more than 275 scientific papers and 30 patents and patent applications. He received his Ph.B. in 1980 from the University of Copenhagen and an honoroary doctoral degree in 1990. He has also received several scientific awards and is a member of EMBO.

Versatile oligo-glycines: The many roles of peptoids in drug discovery
Beta-peptides, gamma-peptides and isosteric backbones: New scaffolds with controlled shapes
Regulation of gene expression with pyrrole-imidazole polyamides
Peptide nucleic acid: A pseudo-peptide with DNA-like properties
Alpha-helical peptide nucleic acids
DNA-cleaving pseudo-peptides

"Das Buch stellt die wichtigsten Eigenschaften und die Vielseitigkeit der Pseudopeptide heraus, mit dem Ziel, neue Entwicklungen in der Wirkstoff-Forschung einzuleiten. Angesichts der aktuellen und detaillierten Darstellung der Themen kann die Lektüre ohne Einschränkung jedermann empfohlen werden, der in der Wirkstoff-Forschung tätig ist, sich mit Pseudopeptiden beschäftigt oder sich für die DNA-Forschung interessiert."

Kiyohiko Kawai, Institute of Scientific and Industrial Research, Universität Osaka, Angewandte Chemie, 2. Novemberheft 2004-116/42 und Angewandte Chemie International Edition, 2nd November Issue 2004-43/42