Phosphoinositides I: Enzymes of Synthesis and Degradation

Buch | Hardcover
356 Seiten
2012
Springer (Verlag)
978-94-007-3011-3 (ISBN)

Lese- und Medienproben

Phosphoinositides I: Enzymes of Synthesis and Degradation -
160,49 inkl. MwSt
Phosphoinositides play a major role in cellular signaling and membrane organization. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

1. The Phosphatidylinositol 4-kinases: Don’t Call it a Comeback.- 2. PIP kinases from the cell membrane to the nucleus.- 3. The Phospholipase C Isozymes and Their Regulation.- 4. Phosphoinositide 3-Kinases – A Historical Perspective.- 5. PI 3-kinases – drug targets in inflammation and cancer.- 6. Phosphoinositide 3-kinases in health and disease.- 7. Phosphoinositide phosphatases: just as important as the kinases.- 8. The PTEN and myobubularin phosphoinositide 3-phosphatases: linking lipid signalling to human disease.

Reihe/Serie Subcellular Biochemistry ; 58
Zusatzinfo XVI, 356 p.
Verlagsort Dordrecht
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Studium 1. Studienabschnitt (Vorklinik) Histologie / Embryologie
Studium 2. Studienabschnitt (Klinik) Humangenetik
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zellbiologie
Naturwissenschaften Biologie Zoologie
ISBN-10 94-007-3011-X / 940073011X
ISBN-13 978-94-007-3011-3 / 9789400730113
Zustand Neuware
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