Small Molecule Therapeutics for Schizophrenia

Sylvain Celanire, Sonia Poli (Herausgeber)

Buch | Hardcover
VII, 323 Seiten
2014 | 2015
Springer International Publishing (Verlag)
978-3-319-11501-6 (ISBN)

Lese- und Medienproben

Small Molecule Therapeutics for Schizophrenia -
106,99 inkl. MwSt
The topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drug ability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine.

Antipsychotics and the Dopamine-Serotonin Connection.- GLYT1 Inhibitors: From Hits to Clinical Candidates.- Metabotropic Glutamate Receptor 2 Activators.- Activation of the mGlu5 Receptor for the Treatment of Schizophrenia and Cognitive-Deficit-Associated Disorders.- Muscarinic Acetylcholine Receptor Activators.- Nicotinic Acetylcholine Receptor Modulators.-The Use of PDE10A and PDE9 Inhibitors for Treating Schizophrenia.

From the book reviews:

"The target audience ... is primarily researchers in psychopharmacology involved in drug development. ... Each chapter concludes with citations of the pertinent scientific literature. This book covering small molecular therapeutics for schizophrenia would be a useful review for researchers studying this area." (Michael Joel Schrift, Doody's Book Reviews, March, 2015)

Erscheint lt. Verlag 30.10.2014
Reihe/Serie Topics in Medicinal Chemistry
Zusatzinfo VII, 323 p. 185 illus., 23 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 660 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Psychiatrie / Psychotherapie
Medizin / Pharmazie Pharmazie
Medizin / Pharmazie Studium
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Chemie Physikalische Chemie
Schlagworte 5HT Receptor Ligands • DA Receptor Ligands • Emergent Targets • GLYT1 Inhibitors • mACh Activators • mGlu2 Activators • mGlu5 Positive Allosteric Modulators • Muscarinic ACh • nACh Activators • Nicotinic ACh Receptor Activators • PDE10/PDE9 Inhibitors • Psychopharmacology • Second Generation Antipsychotics
ISBN-10 3-319-11501-4 / 3319115014
ISBN-13 978-3-319-11501-6 / 9783319115016
Zustand Neuware
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