Introduction to Molecular Vaccinology

Matthias Giese has studied Molecular Biology and Biochemistry at the Saarland University/Germany.  He got a first PhD in Immunology in the German Cancer Research Center/ Heidelberg. In 1994, after Matthias Giese has joined the pharmaceutical industry some years ago, his team in Vienna/ Austria started the first European multicenter clinical trial with a personalized genetic engineered anti-melanoma vaccine.  Also Animal Health was interested in his expertise in modern vaccine technologies and so he changed the company and headed from now on a program on innovative vaccine approaches for the next years.  His sabbatical leave from the industry was a return back to the academic roots. At Leipzig University/ Germany Matthias Giese got a major PhD (venia legendi) in Molecular Virology. Currently he is working again for the human pharmaceutical industry and additionally he teaches graduate students as associate professor. His focus is on neoantigenes, therapeutical vaccines, and the interaction with immune checkpoint modifiers as combination therapy. Matthias Giese is author and editor of “Molecular Vaccines – From Prophylaxis to Therapy” and an enthusiastic mountain marathon runner.

Part I: Scientific Bases.- From Pasteur to personalized vaccines.- Cell biology & Molecular Biology.- Basic vaccine immunology.- Gut and mucosa immunity.- Pediatric immunology.- Elderly immunology.- Tumor immunology.- Part II: Design of vaccines.- Antigen screening/selection processes.- Modes of action of vaccines.- Types of vaccines.- Adjutants.- Nanotechnologies.- Delivery technologies.- In silico vaccine design.- Infection vaccinology.- NINC vaccines.- Tumor vaccinology.- Vet vaccines.- Part III: Production and Public Health Issues.- Formulation.- Biomanufacturing.- Preclinical and clinical trials: basic principles.- Vaccine safety - assessment of adverse effects.- Ethical issues.- Registration process: Evidence-based vaccine trials.- Future vaccines.