Applications of Mass Spectrometry in Microbiology
Springer International Publishing (Verlag)
978-3-319-26068-6 (ISBN)
The emergence of new, antibiotic-resistant strains of human or animal pathogens is of extraordinary concern not only to the scientific and medical communities, but to the general public as well. Developments of novel MS-based assays for rapid identification of strains of antibiotic-resistant microorganisms are reviewed in the book as well. Microbiologists, bioanalytical scientists, infectious disease specialists, clinical laboratory and public health practitioners as well as researchers in universities, hospitals, government labs, and the pharmaceutical and biotechnology industries will find this book to be a timely and valuable resource.
Plamen A. Demirev, Johns Hopkins University Applied Physics LaboratoryTodd Sandrin, School of Mathematical and Natural Sciences, Arizona State University
lt;p>Introduction.- SECTION I. METHODOLOGY AND TECHNIQUES.- Methods and instrumentation in mass spectrometry for the differentiation of closely related microorganisms.- Sample preparation methods for the rapid MS analysis of microorganisms.- Advantages offered by proteomic strategies for rapid biodetection.- Bottom Up Proteomics Methods for Strain-Level Typing and Identification of Bacteria.- Maximizing the taxonomic resolution of MALDI-TOF-MS-based approaches to bacterial characterization: From culture conditions through data analysis.- SECTION II. SUB-SPECIES DISCRIMINATION.-
Modulation of the Discriminatory Power of MALDI-TOF MS Profiling for Distinguishing between Closely Related Bacterial Strains.- Discriminatory Power of MALDI-TOF Mass Spectrometry for Phylogenetically Closely Related Microbial Strains.- MALDI-TOF MS as a novel tool for dereplication and characterization of microbiota in bacterial diversity studies.- Bacterial Identification at the Serovar level by Top-down Mass Spectrometry.- SECTION III. DRUG RESISTANCE MONITORING AND ASSAYS.- Rapid profiling of human pathogenic bacteria and antibiotic resistance employing specific tryptic peptides as biomarkers.- Detection of beta-lactamases and their activity using MALDI-TOF MS.- Stable-isotope based strategies for rapid determination of drug resistance by mass spectrometry.Erscheinungsdatum | 08.10.2016 |
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Zusatzinfo | VIII, 336 p. 68 illus., 36 illus. in color. |
Verlagsort | Cham |
Sprache | englisch |
Maße | 155 x 235 mm |
Themenwelt | Naturwissenschaften ► Chemie ► Analytische Chemie |
Schlagworte | antibacterial drug resistance • applied microbiology • Chemistry and Materials Science • drug resistance • epidemiology • Infectious Diseases • Mass Spectrometry • Microorganism Characterization • MS-based Assay • Strain-level focus |
ISBN-10 | 3-319-26068-5 / 3319260685 |
ISBN-13 | 978-3-319-26068-6 / 9783319260686 |
Zustand | Neuware |
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