From Molecular to Modular Tumor Therapy:

Therapy-Derived Systems Biology: A Pragmatic Communication Theory.- Bridging Theory and Therapeutic Practice: From Generalized Disease Models to Particular Patients.- Tumor Systems Need to be Rendered Usable for a New Action-Theoretical Abstraction: The Starting Point for Novel Therapeutic Options.- Principles of Modular Tumor Therapy.- Tumors Share Common Processes During Tumor Evolution: Communicative Aspects of a Situation’s Interpretation for Creating Systems-Directed Therapies.- Cancer and Coagulation; Focusing on Tissue Factor and Heparanase.- The Role of Mesenchymal Cells in Cancer: Contribution to Tumor Stroma and Tumorigenic Capacity.- Shaping Tumor Associated Macrophages: The Role of NF-?B.- The Metabolic Achilles Heel: Tumor Cell Metabolism as Therapeutic Target.- Could Be Systems-Directed Therapy Approaches Promising in Glioblastoma Patients?.- Systems-Relevant Molecular and Cellular Targets: Implementation of Modular ‘Knowledge’.- Functional Impacts of Signal Integration: Regulation of Inflammation-Related Transcription Factors by Heterotrimeric G Proteins.- Molecular Cross-Talk Between Nuclear Receptors and Nuclear Factor-?B.- The Biomodulatory Capacities of Low-Dose Metronomic Chemotherapy: Complex Modulation of the Tumor Microenvironment.- Tumors are Evolvable Modular and Rationalized Systems: From Molecular to Modular Tumor Therapy.- Systems Biology: A Therapeutic Target for Tumor Therapy.- The Comparative Uncovering of Tumor Systems Biology by Modularly Targeting Tumor-Associated Inflammation.- Searching for the ‘Metabolism’ of Evolution.- Biomodulatory Therapy Approaches in Metastatic Cancer.- The Impact of Inflammation Control and Active Cancer Palliation on Metabolic Pathways Determining Tumor Progression and Patient Survival.-Pioglitazone and Rofecoxib Combined with Angiostatically Scheduled Capecitabine in Far-Advanced Hepatobiliary Carcinoma.- C-Reactive Protein As a Secretome-Derived Biomarker for Predicting Response to Biomodulatory Therapy in Metastatic Renal Clear Cell Carcinoma.- Modular Therapy Approach in Metastatic Castration-Resistent Prostate Cancer.- Systems-Directed Therapy in Metastatic Castration-Resistent Prostate Cancer (CRCP).- Criteria for Checking Systems Behavior and Creating Predictions: Systems-Associated Biomarkers and Molecular Imaging.- Early Detection of Systems Response: Molecular and Functional Imaging of Angiogenesis.- Secretome Proteomics, a Novel Tool for Biomarkers Discovery and for Guiding Biomodulatory Therapy Approaches.- Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma.- Pharmacological Considerations on Systems Biological Therapy Approaches.- Uncovering Tumor Systems Biology by Biomodulatory Therapy Strategies.- Breathing New Life into Old Drugs: Indication Discovery by Systems Directed Therapy.- Tumors’ Systems Biology: Implications for Personalized Therapy.- A Methodological Approach to Personalized Therapies in Metastatic Cancer.- Summary.- To Be an Object in a Biological System.- From Molecular to Modular, from Theme-Dependent to Evolution-Adjusted Tumor Therapy.