Artificial Sight (eBook)

Basic Research, Biomedical Engineering, and Clinical Advances
eBook Download: PDF
2007 | 2007
XXIV, 400 Seiten
Springer New York (Verlag)
978-0-387-49331-2 (ISBN)

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This book describes advances in implantable neural stimulation technology to restore partial sight to people who are blind from retinal degnerative diseases such as age-related macular degeneration and retintis pigmentosa. Many scientific, engineering, and surgical challenges must be surmounted before widespread practical applications can be realized. The book summarizes the state of research and clinical practice in the field and reviews the current ideas and approaches of its leading researchers and practitioners.



The Editors are active researchers in the fields of artificial sight, biomedical engineering and biological physics. They have received numerous professional awards and recognition for their work. The artificial sight team at the Doheny Eye Institute, led by Dr. Mark Humayun, is a world leader in this area of biomedical engineering and clinical research.


Artificial sight is a frontier area of modern ophthalmology combining the multidisciplinary skills of surgical ophthalmology, biomedical engineering, biological physics, and psychophysical testing. Many scientific, engineering, and surgical challenges must be surmounted before widespread practical applications can be realized. The goal of Artificial Sight is to summarize the state-of-the-art research in this exciting area, and to describe some of the current approaches and initiatives that may help patients in a clinical setting. The Editors are active researchers in the fields of artificial sight, biomedical engineering and biological physics. They have received numerous professional awards and recognition for their work. The artificial sight team at the Doheny Eye Institute, led by Dr. Mark Humayun, is a world leader in this area of biomedical engineering and clinical research.Key FeaturesIntroduces and assesses the state of the art for a broad audience of biomedical engineers, biophysicists, and clinical researchersDescribes advances in microelectronics, microfabrication, surgical implantation, and psychophysical testing of visual prosthesesOutlines the promise of artificial sight and the challenges that must be met

The Editors are active researchers in the fields of artificial sight, biomedical engineering and biological physics. They have received numerous professional awards and recognition for their work. The artificial sight team at the Doheny Eye Institute, led by Dr. Mark Humayun, is a world leader in this area of biomedical engineering and clinical research.

Series Preface 6
Preface 7
Contents 8
List of Contributors 14
List of Acronyms 20
Biological Considerations for an Intraocular Retinal Prosthesis 23
Artificial Vision: Vision of a Newcomer 52
The Effects of Visual Deprivation: Implications for Sensory Prostheses 67
Prosthetic Vision Simulation in Fully and Partially Sighted Individuals 91
Testing Visual Functions in Patients with Visual Prostheses 111
The IMI Retinal Implant System 131
Challenges in Realizing a Chronic High- Resolution Retinal Prosthesis 149
Large-scale Integration–Based Stimulus Electrodes for Retinal Prosthesis 170
Development of a Wireless High- Frequency Microarray Implant for Retinal Stimulation 188
Visual Prosthesis Based on Optic Nerve Stimulation with Penetrating Electrode Array 206
Dynamic Interactions of Retinal Prosthesis Electrodes with Neural Tissue and Materials Science in Electrode Design 227
In Vitro Determination of Stimulus- Induced pH Changes in Visual Prostheses 245
Electrochemical Characterization of Implantable High Aspect Ratio Nanoparticle Platinum Electrodes for Neural Stimulations 260
High-Resolution Opto-Electronic Retinal Prosthesis: Physical Limitations and Design 272
Computational Modeling of Electromagnetic and Thermal Effects for a Dual- Unit Retinal Prosthesis: Inductive Telemetry, Temperature Increase, and Current Densities in the Retina 295
Microstimulation with Chronically Implanted Intracortical Electrodes 322
A Tissue Change After Suprachoroidal- Transretinal Stimulation with High Electrical Current in Rabbits 339
Electrical Stimulation of Mammalian Retinal Ganglion Cells Using Dense Arrays of Small- Diameter Electrodes 347
A Mechanism for Generating Precise Temporal Patterns of Activity Using Prosthetic Stimulation 360
Electrophysiology of Natural and Artificial Vision 368
Index 394

Erscheint lt. Verlag 30.9.2007
Reihe/Serie Biological and Medical Physics, Biomedical Engineering
Zusatzinfo XXIV, 400 p. 224 illus. in color.
Verlagsort New York
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Augenheilkunde
Medizin / Pharmazie Medizinische Fachgebiete Chirurgie
Naturwissenschaften Biologie
Naturwissenschaften Physik / Astronomie Angewandte Physik
Technik Bauwesen
Schlagworte biomedical engineering • biomedical engineers • biotelemetry • Electromagnetic • Implantat • Physiology • Temperature • tissue
ISBN-10 0-387-49331-X / 038749331X
ISBN-13 978-0-387-49331-2 / 9780387493312
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