Molecular Basis of Human Cancer (eBook)

William B. ColemanDepartment of Pathology and Laboratory medicine, Curriculum in Toxicology, Program in Translational Medicine, UNC Lineberger Comprehensive Center, University of North Carolina School of Medicine, Chapel Hill, NC

Chapter 1Cancer Epidemiology: Incidence and Etiology of Human NeoplasmsWilliam B. Coleman and Gregory J. TsongalisChapter 2Essential Concepts and Techniques in Molecular BiologyClaudine L. Lefferts, PhD and Joel A. Lefferts, PhDChapter 3Cancer GenomicsJonathan R. PollackChapter 4Cancer CytogeneticsThomas Ried, Kerstin Heselmeyer-Haddad, Jordi Camps, and Timo GaiserChapter 5The Epigenetic Basis of Human CancerThomas Mikeska and Alexander DobrovicChapter 6Cancer ProteomicsJeffrey M. Lake and Timothy D. VeenstraChapter 7An Overview of Cancer GenesAshley G. Rivenbark, PhDChapter 8Oncogenes and the Initiation and Maintenance of TumorigenesisDean W. Felsher, Constadina Arvanitis, Pavan Bendapudi, and Pavan BachireddyChapter 9Positive Mediators of Cell Proliferation in Neoplasia: Growth Factors and ReceptorsLuca Grumolato, Ph.D. and Stuart Aaronson, M.D.Chapter 10Senescence, Apoptosis, and CancerManjari Dimri and Goberdhan P. DimriChapter 11Novel Cancer Therapies Targeting AngiogenesisMonte Willis and Nancy Klauber-DeMoreChapter 12Beyond the Primary Tumor: Progression, Invasion, and MetastasisDanny R. Welch, Ph.D. and Douglas R. Hurst, Ph.D.Chapter 13Simple Sequence MutationsChristophe Béroud and Mireille ClaustresChapter 14Single Nucleotide Polymorphisms and Cancer SusceptibilityRichard A. Hubner and Richard S. HoulstonChapter 16Chromosomes and Chromosomal Instability in Human CancerKazuma Ohyashiki, Masahiko Kuroda, and Junko H. OhyashikiChapter 17Epigenetic Mechanisms in Cancer DevelopmentJosé Ignacio Martín-Subero and Manel EstellerChapter 18MicroRNAs and CancerPhong Trang, Joanne Weidhaas, and Frank J. SlackChapter 19Erionite and Asbestos in the Pathogenesis of Human Malignant MesotheliomasMutlay Sayan and Brooke T. MossmanChapter 20Viral Mechanisms in Human CarcinogenesisPaul F. Lambert, PhDChapter 21Hormonal Carcinogenesis: The Role of EstrogensWilliam A. Ricke, Karin Williams, Jalissa Wynder, Ganesh Palapattu, Yuzhuo Wang, Gerald R. CunhaChapter 22Sporadic CancersClemens B. Tempfer and Marc-André ReymondChapter 23Hereditary CancerZoran Gatalica, MD, DSc, Anatole Ghazalpour, PhD Stan L. Lilleberg, PhD, Jeffrey Swensen, PhD, and Henry T. Lynch, MDChapter 24Retinoblastoma:  Clinical and Molecular PerspectivesJustis P. Ehlers MD and J. William Harbour MDChapter 25Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet LightJames E. CleaverChapter 26Hereditary Colorectal CancerSonia S. Kupfer and Nathan A. EllisChapter 27LungsMichael P. Lux, Mayada R. Bani, Peter A. Fasching, and Matthias W. BeckmannChapter 28The Molecular Basis of Prostate CarcinogenesisSmitha Dutt and Allen C. GaoChapter 29Molecular Basis of Lung CarcinogenesisKwun M. Fong, Jill E. Larsen, Casey Wright, Krishna Sriram, Morgan Davidson, Marissa Daniels, Yoshitaka Sekido, Rayleen V. Bowman, Ian A. Yang, and John D. MinnaChapter 30The Molecular Basis of Skin CarcinogenesisAlessia Pacifico, MD, Giovanni Leone, MD, Honnavara N. Ananthaswamy, PhDChapter 31The Molecular Biology of LeukemiasL. Jeffrey Medeiros and Sergej N. KonoplevChapter 32Molecular Mechanisms in Non-Hodgkin LymphomaJohn Hunt, MD, Yuri Fedoriw, MD and William N. Rezuke, Jr., MDChapter 33The Molecular Pathology of Head and Neck Squamous Cell CarcinomaLaura J. TafeChapter 34Ovarian CancerAmy D. Brockmeyer and Louis Dubeau, MD, PhDChapter 35Molecular Pathology of Bone and Soft Tissue TumorsJosé Luis Ordóñez PhD, Daniel Osuna PhD, Juan Madoz-Gúrpide PhD, Enrique de Álava, MD, PhDChapter 36The Molecular Biology of Human Brain TumorsDaniel Coluccia, Adrienne Weeks, Javier Fandino, Christian Schneider, Christian Smith, and James T. RutkaChapter 37Cancer Drug Discovery and Anticancer Drug DevelopmentJames Turkson, PhDChapter 38HeartZhuo (Georgia) Chen, PhD, Suresh Ramalingam, MD, and Dong M. Shin, MDChapter 39Targeting Oncoproteins for Molecular Cancer TherapyJoshua E. Allen and Wafik S. El-DeiryChapter 40Therapeutic Agents that Inhibit AngiogenesisFrancesco Torino, Roberta Sarmiento, Raffaelle Longo, and Giampietro GaspariniChapter 41Small Molecule InhibitorsXin Chen, Ph.D. and Jian Jin, Ph.DChapter 42Molecular Detection and Diagnosis of CancerChristos Patriotis, Padma Maruvada, and Sudhir SrivastavaChapter 43Gene Therapy in the Treatment of Human CancerAnand C. Annan, MBBS, Paul B. Fisher, MPh, PhD, Paul Dent, PhD, Gene P. Siegal, MD, PhD, David T. Curiel, MD, PhDChapter 44Personalized Medicine for the Treatment of Human CancerScott A. Turner, PhD and Gregory J. Tsongalis, PhD