A Comprehensive Guide to Core Needle Biopsies of the Breast

Sandra J. Shin, MD Professor and Chairman Department of Pathology and Laboratory Medicine Albany Medical College Pathologist-in-Chief and Director of Laboratories Albany Medical Center Hospital 47 New Scotland Avenue, Room F117 MC 81 | Albany, NY 12208 518-262-5461; shins1@amc.edu Yunn-Yi Chen, MD, PhD Professor Director of Immunohistochemistry Laboratory Department of Pathology University of California San Francisco 1825 4th Street, Room M-2358 San Francisco, CA 94143 415-353-1613; yunn-yi.chen@ucsf.edu. Paula S. Ginter, MD Associate Professor of Pathology and Laboratory Medicine Weill Cornell Medicine 525 East 68th Street Starr 1013-B New York, NY 10065 212-746-4065; psg9003@med.cornell.edu

Essential Components of a Successful Breast Core Needle Biopsy Program: Imaging Modalities, Sampling Techniques, Specimen Processing, Radiologic/Pathologic Correlation, and Appropriate Follow-Up.- Pattern-Based Evaluation of Breast Core Needle Biopsies.- Multiples in Core Biopsy Samples.- Inflammatory, Reactive, and Infectious Conditions of the Breast.- Adenosis, Sclerosing Lesions, Microglandular Adenosis, and Mucocele-Like Lesions.- Papillary Tumors and Epithelial and Myoepithelial tumors (Pleomorphic adenoma, Adenomyoepithelioma, Malignant Adenomyoepithelioma).- Fibroepithelial Lesions.- Columnar Cell Lesions.- Intraductal Proliferations (UDH, ADH, DCIS).- Invasive Ductal Carcinoma, NST (including microinvasive carcinoma), Tubular Carcinoma, and Cribriform Carcinoma.- Triple-Negative/Basal-Like Breast Carcinomas.- Less Common Triple-Negative Breast Cancers and Salivary Gland-Type Tumors (Carcinoma with Apocrine differentiation, Metaplastic carcinoma, Adenoid Cystic Carcinoma, Secretory Carcinoma, Acinic Cell Carcinoma, Mucoepidermoid carcinoma, Tall Cell Carcinoma with Reversed Polarity).- Special Histologic Types and Special Morphologic Patterns of Invasive Ductal Carcinoma, NST (Mucinous, Micropapillary, Mucinous Cystadenocarcinoma, Cystic Hypersecretory, Glycogen-Rich Clear Cell, Carcinoma with Osteoclast-Like Giant Cells, Neuroendocrine Neoplasms).- Atypical Lobular Hyperplasia and Lobular Carcinoma In Situ.- Invasive Lobular Carcinoma.- Benign and Malignant Mesenchymal Tumors.- Vascular Lesions of the Breast.- Breast Tumors in Adolescents/Children and Males.- Lesions of the Nippe.- Lymphoid and Hematopoietic Tumors of the Breast.- Special Clinical Settings: Tumors Arising in Pregnancy, Pregnancy-Like (Pseudolactational) Proliferations, Breast Carcinoma in the Pre-neoadjuvant Chemotherapy Setting, Recurrent Breast Carcinoma, and Inflammatory Breast Carcinoma.- Current Standard Clinical Predictive Markers.- Future Role of Molecular Profiling in Small Breast Samples and Personalized Medicine.- Metastases to the Breast.- Dermatologic Mimickers of Breast Lesions Arising in the Breast Skin, Subcutis, or Axilla.