Molecular Cell Biology

Part 1 Laying the groundwork: the dynamic cell; chemical foundations; protein structure and function; nucleic acids, the genetic code, and the synthesis of macromolecules; biomembranes and the subcellular organization of eukaryotic cells; manipulating cells and viruses in culture; recombinant DNA technology; genetic analysis in cell biology. Part 2 Nuclear control of cellular activity: molecular structure of genes and chromosomes; regulation of transcription initiation; RNA processing, nuclear transport, and post-transcriptional control; DNA replication, repair, and recombination; regulation of the eukaryotic cell cycle; gene control in development. Part 3 Building and fuelling the cell: transport across cell membranes; cellular energetics - glycolysis, aerobic oxidation, and photosynthesis; protein sorting - organelle biogenesis and protein secretion; cell motility and shape I - microfilaments; cell motility and shape II - microtubules and intermediate filaments. Part 4 Cell interactions: cell-to-cell signalling - hormones and receptors; nerve cells; integrating cells into tissues; dynamic cells interactions; cancer.