Notch Signaling in Embryology and Cancer

Sandra and Jörg Reichrath are working at the Clinic for Dermatology; Allergology and Venerology of the Saarland University Hospital in Homburg/Saar. Germany. Main research interests include photobiology, carcinogenesis of skin cancer (with a special interest for the role of ultraviolet radiation, Notch and p53), and the relevance of the vitamin D endocrine system for health and disease. Sandra received her academic degrees (Dipl. Biol. and Dr. rer. nat.) from the Albert-Ludwigs-Universität (Freiburg, Germany) and from Saarland University (Saarbrücken/Homburg, Germany), respectively. Jörg received his academic degrees (Dr. med., venia legendi) from Saarland University (Saarbrücken/Homburg, Germany). He has been awarded numerous prizes including the Arnold-Rikli-Prize in 2006.

Challenge and Promise: A Snap-Shot on the Molecular Biology of Notch Signaling.- Overview of Basic Mechanisms of Notch Signaling in Development and Disease.- Ligand-induced cis-inhibition of Notch signaling: the role of an extracellular region of Serrate.- Phosphorylation and proteolytic cleavage of Notch in canonical and non-canonical Notch signaling.- Maheshvara a conserved RNA helicase regulates Notch signaling in Drosophila melanogaster.- Molecular Regulation of Notch Signaling by Gremlin.- Regulation of Notch Signaling in Drosophila melanogaster: the role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex.- Interaction of Long Non-Coding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss.- Insulin-dependent non-canonical activation of Notch in Drosophila: a story of Notch-induced muscle stem cells proliferation.- Molecular mechanisms of Notch signaling in lymphoid cell lineages development: NF- B and beyond.- Index.