The Myc Gene

An “-omycs” Toolbox to Work with MYC.- Methods of Expression, Purification and Preparation of the c-Myc b-HLH-LZ for its Biophysical Characterization.- Biophysical and Structural Methods to Study the bHLHzip Region of Human c-MYC.- Identifying and Validating MYC:protein Interactors in Pursuit of Novel anti-MYC Therapies.- Detection of Post-Translational Modifications on MYC.- MYC Analysis in Cancer and Evolution.- Genome-wide analysis of c-MYC-regulated mRNAs and miRNAs, and c-MYC DNA-binding by Next Generation Sequencing.- Analysis of Myc Chromatin Binding by Calibrated ChIP-seq Approach.- A High-Throughput Chromatin Immunoprecipitation Sequencing Approach to Study the Role of MYC on the Epigenetic Landscape.- Methods for Determining Myc-induced Apoptosis.- Measuring MYC-mediated Metabolism in Tumorigenesis.- Methods to study Myc-regulated Cellular Senescence – An Update.- Examining Myc-Dependent Translation Changes in Cellular Homeostasis and Cancer.- A Versatile in vivo System to Study Myc in Cell Reprogramming.- Using Flow Cytometry to Study Myc’s Role in Shaping the Tumor Immune Microenvironment.- Generation of a Tetracycline Regulated Mouse Model of MYC-Induced T-Cell Acute Lymphoblastic Leukemia.- Chromogenic in Situ Hybridization (CISH) as a Method for Detection of C-Myc Amplification in Formalin-Fixed Paraffin-Embedded Tumor Tissue: An Update.- MYC Copy Number Detection in Clinical Samples using a Digital DNA-Hybridization and Detection Method.- Cell-Based Methods for the Identification of Myc-Inhibitory Small Molecules.