Biochemistry

JEREMY M. BERG is Director of the National Institute of General Medical Sciences at the National Institute of Health, USA. He is the recipient of the American Chemical Society Award in Pure Chemistry (1994), the Eli Lilly Award for Fundamental Research in Biological Chemistry (1995), the Maryland Outstanding Young Scientist of the Year (1995) and the Harrison Howe Award (1997). JOHN L. TYMOCZKO is the Towsley Professor of Biology at Carleton College, USA, where he has taught since 1976. LUBERT STRYER is Winzer Professor of Cell Biology, Emeritus, in the School of Medicine and Professor of Neurobiology, Emeritus, at Stanford University, USA, where he has been on the faculty since 1976. He was elected to the National Academy of Sciences in 1984.

PART I: THE MOLECULAR DESIGN OF LIFE Biochemistry: An Evolving Science Protein Composition and Structure Exploring Proteins and Proteomes DNA, RNA and the Flow of Genetic Information Exploring Genes and Genomes Exploring Evolution and Bioinformatics Hemoglobin: Portrait of a Protein in Action Enzymes: Basic Concepts and Kinetics Catalytic Strategies Regulatory Strategies Carbohydrates Lipids and Cell Membranes Membrane Channels and Pumps Signal Transduction Pathways PART II: TRANSDUCING AND STORING ENERGY Metabolism: Basic Concepts and Design Glycolysis and Gluconeogenesis The Citric Acid Cycle Oxidative Phosphorylation The Light Reactions of Photosynthesis The Calvin Cycle and the Pentose Phosphate Pathway Glycogen Metabolism Fatty Acid Metabolism Protein Turnover and Amino Acid Catabolism PART III: SYNTHESIZING THE MOLECULES OF LIFE The Biosynthesis of Amino Acids Nucleotide Biosynthesis The Biosynthesis of Membrane Lipids and Steroids The Integration of Metabolism DNA Replication, Repair and Recombination RNA Synthesis and Processing Protein Synthesis The Control of Gene Expression PART IV: RESPONDING TO ENVIRONMENTAL CHANGES Sensory Systems The Immune System Molecular Motors Drug Development