Molecular and Biological Aspects of the Acute Allergic Reaction

Session I Structure of Allergens and Regulation of IgE Immune Response.- Common Characteristics of Major Allergens.- Allergy: A Model for Studying the Genetics of Human Immune Response.- Induction and Suppression of IgE Antibody Response.- T Cell-Mediated Regulation of IgE Antibody Production.- Session II IgE In Rats: An Experimental Model.- Production of IgE and Reaginic Antibody in Rats in Relation to Worm Infections.- IgE-Myelomas in Rats.- Macrophage Cytotoxicity Mediated by IgE Antibody.- Session III IgE-Dependent Activation and Release of Chemical Mediators.- Function and Structure of Immunoglobulin E (IgE).- Functions and Development of Cell Receptors for IgE.- Modes of Action of Antigen-Antibody Reaction and Compound 48/80 in Histamine Release.- Discussion Remark: Protein Kinases in Rat Mast Cells.- The Interdependence of Allergic and Inflammatory Processes.- Influence of Calcium Ions and Metabolic Energy (ATP) on Histamine Release.- Molecular Events in Membrane Fusion Occurring During Mast Cell Degranulation.- Mast Cell-Derived Mediators: Structural and Functional Diversity and Regulation of Expression.- Prostaglandins and Related Substances in Acute Allergie Reactions.- Session IV Generation of Biologically Active Substances and Mediator - Target Cell Interactions.- The Anaphylatoxins: Formation, Structure, Function and Control.- Some Interrelations Among Chemotaxis, Lysosomal Enzyme Secretion and Phagocytosis by Neutrophils.- The Hageman Factor System: Mechanism of Contact Activation.- Neutrophil Generation of Permeability Enhancing Peptides from Plasma Substrates.- Specificity and Modulation of the Eosinophil Polymorphonuclear Leukocyte Response to the Eosinophil Chemotactic Factor of Anaphylaxis (ECF-A).- Lymphocyte Mediators, Activated Macrophages, and Tumor Immunity.- Participants.