Tissue Engineering and Regeneration in Dentistry

Rachel J. Waddington is Professor in Oral Biochemistry and current Associate Dean for Engagement and Enterprise at the School of Dentistry, Cardiff University, UK. Her research interests centre on the cellular and matrix biology of bone and dentine and applying this research to improved diagnosis, management, and treatment in clinical dentistry, with crossover to orthopaedic medicine. She has published more than 80 papers in peer-reviewed journals, and supervised over 20 PhD students. During her career Rachel has been awarded the Senior Colgate Prize (1990) and the Mineralised Tissue Group Travel Award (1996), both awarded by the British Society for Oral and Dental Research (BSODR), and a Royal Society overseas study award. She is an active member of the BSODR, currently sitting on the Management Committee as Chair of the Awards Committee. Alastair J. Sloan is Professor in Bone Biology and Tissue Engineering and current Vice-Dean of Research and International at the School of Dentistry, Cardiff University, UK. His research focuses on the repair and regeneration of mineralized tissues and the behaviour and therapeutic use of dental pulp stem cells. His research has been widely published in peer-reviewed journals. Alastair currently sits on the Management Committee of the British Society for Oral and Dental Research (BSODR) and the Board of the Tissue and Cell Engineering Society UK (TCES), and is Chair of the Cardiff Institute of Tissue Engineering and Repair (CITER). In 2011 Alastair was awarded the International Association for Dental Research Distinguished Scientist – Young Investigator Award.

List of contributors, vi

Preface, viii

1 Induced pluripotent stem cell technologies for tissue engineering, 1
George T.‐J. Huang, Ikbale El Ayachi, and Xiao‐Ying Zou

2 Immunomodulation by adult stem cells: Mechanisms of action and clinical applications, 20
Lindsay C. Davies and Katarina Le Blanc

3 Research advances in tissue regeneration by dental pulp stem cells, 50
Rachel J. Waddington and Alastair J. Sloan

4 Assessing the potential of mesenchymal stem cells in craniofacial bone repair and regeneration, 69
Rachel J. Waddington, S. Quentin Jones, and Ryan Moseley

5 Tissue culture models and approaches for dental tissue regeneration, 96
Alastair J. Sloan, John Colombo, Jessica Roberts, Rachel J. Waddington, and Wayne Nishio Ayre

6 Industrial translation requirements for manufacture of stem cell–derived and tissue‐engineered products, 110
Ivan Wall, David de Silva Thompson, Carlotta Peticone, and Roman Perez

7 Periodontal tissue engineering, 124
Saso Ivanovski, P. Mark Bartold, Stan Gronthos, and Dietmar W. Hutmacher

8 Clinical strategies for dental and periodontal disease management: A way forward, 145
Anibal Diogenes, Vanessa Chrepa, and Nikita B. Ruparel

Index, 169