Multifunctional Proteins

James F. Kane , Ph.D. , received his undergraduate degree from St. Joseph’s University in June of 1964. After one year of graduate work at the Biology Department of St. Louis University, he completed a Ph.D. degree in Biology, with emphasis on cellular physiology and biochemistry, at the State University of New York at Buffalo in February, 1969., Dr. Kane received an NIH Postdoctoral Fellowship (1968–70) and pursued studies in microbial physiology and biochemistry with Dr. Roy A. Jensen at the Department of Microbiology of Baylor College of Medicine in Houston, Texas. He subsequently took a position in the Department of Microbiology at the University of Tennessee Center for Health Sciences, and remained at UTCHS until June, 1980., Presently Dr. Kane is a Senior Research Specialist in the Corporate Research Laboratories of Monsanto Company in St. Louis, Missouri. He is a member of the American Society for Microbiology and the Federation of Biological Chemists. His research interests include the evolution of multifunctional proteins and their role in regulation of cellular activity., Jean E. Brenchley, Research Director, Genex Corporation, Gaithersburg, Maryland, Daniel H. Doherty, Research Associate, M.C.D.B., University of Colorado, Boulder, Colorado, Peter Gauss, Research Associate, M.C.D.B. Biology, University of Colorado, Boulder, Colorado, Larry Gold, Professor, M.C.D.B. Biosciences, University of Colorado, Boulder, Colorado, James F. Kane , Ph.D., Senior Scientist, Montsanto Company, St. Louis, Missouri, John E. Leonard, Postdoctoral Fellow, Cancer Center, University of California at San Diego, La Jolla, California, Rolf Menzel, National Institutes of Health, Bethesda, Maryland, Masayasu Nomura, Ph.D., Professor, Institute for Enzyme Research, University of Wisconsin, Madison, Wisconsin, Milton Saier , Ph.D., Professor, Department of Biology, University of California at San Diego, La Jolla, California, Rudolph Spangler, Faculty Fellow, Department of Biological Sciences, Columbia University, New York, New York, John Yates , Ph.D., Post-doctorate, McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin, Geoffrey Zubay, Professor, Department of Biological Sciences, Columbia University, New York, New York

1. Introduction. 2. The Mannitol Enzyme of the Bacterial Phospho-Transferase System: A Functional Chimeric Protein with Receptor, Transport, Kinase, and Regulatory Activities. 3. Escherichia coli Ribosomal Proteins Involved in Autogenous Regulation of Translation. 4. The Single-Stranded DNA Binding Protein of Bacteriophage T₄. 5. Regulation of Synthesis of the Beta and Beta¹ Subunits of the RNA Polymerase of Escherichia coli. 6. Puta Gene: Two Enzymatic Activities and a Regulatory Function in a Single Polypeptide. 7. Consideration of Glutamine Synthetase as a Multifunctional Protein. Index.