Non-traditional Approaches to Combat Antimicrobial Drug Resistance (eBook)

This book provides a detailed overview of the progress and challenges of non-traditional approaches for tackling antimicrobial resistance. The first chapter covers the factors that make microbes more likely to develop multidrug resistance. The book goes on to discuss the antimicrobial properties of propolis, essential oils and other microbial constituents that are used or under investigation to treat multidrug-resistant infections. Additionally, it covers alternative compounds that work as antimicrobial agents, their mechanisms of action, and how they might be utilized in conjunction with conventional drugs to circumvent drug resistance. The book explores the application of phage therapy and recent advancements in phage-based infection control with an emphasis on multidrug-resistant infections and discusses drug repurposing as a strategy to develop new antimicrobial agents efficiently and expeditiously. Additionally, it discusses the uses of nanoparticles in the treatment of infections brought on by multidrug-resistant pathogens and examines the use of different nanotechnology-based approaches to fudge microbial resistance mechanisms. It concludes by reviewing recent studies on microbial quorum-sensing systems and focuses on the significance of quorum-sensing systems in controlling microbial resistance mechanisms and at the same time highlights the importance and role of antimicrobial stewardship program to fight microbial infections. The book is an invaluable source of knowledge and information for academics, basic and clinical researchers, clinicians, and paramedic staff involved in one way or the other in the development and use of antimicrobial agents and strategies to combat multidrug resistance.?

Dr. Wani, is an associate professor of Organic and Medicinal Chemistry in the College of Science, University of Jeddah, Jeddah, Saudi Arabia. He received his Ph.D. in Organic and Medicinal Chemistry from Jamia Millia Islamia, New Delhi, India, and Postdoctoral training from the University of Coimbra, Portugal, and Texas Therapeutics Institute, UTHealth, Houston, Texas, USA on the development of new treatment strategies and non-traditional approaches to combat antimicrobial drug resistance (AMR). With an extensive experience in the field of medicinal chemistry and drug discovery, he has authored/co-authored over 50 peer-reviewed research articles and 04 books, and is the recipient of many prestigious honors, awards, and grants. He is a professional member of many scientific societies and is on the editorial board of many reputed scientific journals. Dr. Wani is working at the interface of chemistry and biology to advance the field with new questions and pertinent issues of 21^st century.

Dr. Aijaz Ahmad, is a Senior Medical Scientist in the Division of Infection Control of National Health Laboratory Service at Charlotte Maxeke Johannesburg Academic Hospital and a Lecturer in the Department of Clinical Microbiology and Infectious Diseases, School of Pathology, University of the Witwatersrand. His core research interest is understanding fungal pathogenesis and development of antifungal vaccines and novel antifungal drugs. He has obtained his Ph.D. in Medical Mycology. During his trainings as a Postdoctoral Scientist from different institutions, he gained lot of experience to be a medical microbiologist. He is an HPCSA registered Medical Scientist in Microbiology and is also National Research Foundation (NRF) rated researcher. With an extensive research experience in infectious diseases, microbial pathogenesis, and drug development, he has authored/co-authored over 90 peer-reviewed publications, supervised more than 25 postgraduate students, and is recipient of several research grants and awards.

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This book provides a detailed overview of the progress and challenges of non-traditional approaches for tackling antimicrobial resistance. The first chapter covers the factors that make microbes more likely to develop multidrug resistance. The book goes on to discuss the antimicrobial properties of propolis, essential oils and other microbial constituents that are used or under investigation to treat multidrug-resistant infections. Additionally, it covers alternative compounds that work as antimicrobial agents, their mechanisms of action, and how they might be utilized in conjunction with conventional drugs to circumvent drug resistance. The book explores the application of phage therapy and recent advancements in phage-based infection control with an emphasis on multidrug-resistant infections and discusses drug repurposing as a strategy to develop new antimicrobial agents efficiently and expeditiously. Additionally, it discusses the uses of nanoparticles in the treatment of infectionsbrought on by multidrug-resistant pathogens and examines the use of different nanotechnology-based approaches to fudge microbial resistance mechanisms. It concludes by reviewing recent studies on microbial quorum-sensing systems and focuses on the significance of quorum-sensing systems in controlling microbial resistance mechanisms and at the same time highlights the importance and role of antimicrobial stewardship program to fight microbial infections. The book is an invaluable source of knowledge and information for academics, basic and clinical researchers, clinicians, and paramedic staff involved in one way or the other in the development and use of antimicrobial agents and strategies to combat multidrug resistance.?