Application of Basic Neuroscience to Child Psychiatry

1. Introduction.- 2. Brain Imaging Studies of Autism.- 3. Regulation of Neuritic Extension.- 4. Transplantation and Cellular Replacement Therap.- References.- I. BASIC NEUROSCIENCE CONSIDERATIONS.- 1. Molecular Neurobiology and Disorders of Brain Development.- 2. Neurotransmitter Assessment in Neuropsychiatric Disorders of Childhood.- 3. Role of the GABA-Benzodiazepine Receptor Complex in Stress: In Vivo Approaches and Potential Relevance to Childhood Psychopathology.- 4. Brain Recognition Sites for Methylphenidate and the Amphetamines: Their Relationship to the Dopamine Transport Complex, Glucoreceptors, and Serotonergic Neurotransmission in the Central Nervous System.- 5. Neuropeptide Modulation of Development and Behavior: Implications for Psychopathology.- 6. Drug Discrimination Studies in Animals: A Behavioral Approach to Understanding the Role of Neurotransmitter Receptor Complexes in Mediating Drug Effects.- 7. The Platelet as a Peripheral Model of Serotonergic Function in Child Psychiatry.- 8. Neuroendocrine Abnormalities in Autism and Schizophrenic Disorder of Childhood.- 9. Autoimmune Dysfunction in Neurodevelopmental Disorders of Childhood.- 10. Nonketotic Hyperglycinemia: A Paradigm for the Application of Neuroscience to the Understanding and Treatment of a Developmental Disorder.- II. APPLICATION TO SPECIFIC CLINICAL DISORDERS.- 11. Genetic Causes of Autism and the Pervasive Developmental Disorders.- 12. Biological Studies of Schizophrenia with Childhood Onset.- 13. Biological Studies of Attention-Deficit Disorder.- 14. Biochemical and Genetic Studies of Tourette’s Syndrome: Implications for Treatment and Future Research.- 15. Obsessive-Compulsive Disorder: Neurologic and Neuroanatomic Perspectives.- 16. Neurochemical and Neuroendocrine Considerations ofObsessive-Compulsive Disorders in Childhood.- 17. The Genetics of Affective Disorder.- 18. Biochemical Correlates of Auto-Aggressive Behavior: Inferences from the Lesch-Nyhan Syndrome.- 19. Biochemical Studies of Suicide.- 20. Relationship of Down’s Syndrome to Alzheimer’s Disease.- III. EVALUATION, DRUG DEVELOPMENT, AND ETHICAL CONSIDERATIONS.- 21. Neuropsychological Evaluation of Children.- 22. Evaluation of the Violent Adolescent.- 23. Novel Drug Development in the Developmental Disorders.- 24. Ethical Issues in Research in Child Psychiatry.