Fatty Acids

Part I. Basic Mechanisms

Evolutionary Aspects of Diet: Essential Fatty Acids
Artemis P. Simopoulos

Modulation of Receptor Signaling by Phospholipid Acyl Chain Composition
Drake C. Mitchell and Burton J. Litman

Role of Docosahexaenoic Acid in Determining Membrane Structure and Function: Lessons Learned from Normal and Neoplastic Leukocytes
Laura J. Jenski and William Stillwell

Effects of Essential Fatty Acids on Voltage-Regulated Ionic Channels and Seizure Thresholds in Animals
Robert A. Voskuyl and Martin Vreugdenhil

Role of Dietary Fats and Exercise in Immune Functions and Aging
Jaya T. Venkatraman and David Pendergast

Part II. Phospholipid and Fatty Acid Composition and Metabolism

On the Relative Efficacy of _-Linolenic Acid and Preformed Docosahexaenoic Acid as Substrates for Tissue Docosahexaenoate During Perinatal Development
Meng-Chuan Huang and J. Thomas Brenna

Recent Advances in the Supply of Docosahexaenoic Acid to the Nervous System
Robert J. Pawlosky and Norman Salem Jr

Quantifying and Imaging Brain Phospholipid Metabolism In Vivo Using Radiolabeled Long Chain Fatty Acids
Stanley I. Rapoport

Carbon Recycling: An Important Pathway in _-Linolenate Metabolism in Fetuses and Neonates
Stephen C. Cunnane

Part III. DHA and CNS Development

Impact of Dietary Essential Fatty Acids on Neuronal Structure and Function
M. Thomas Clandinin, R.A.R. Bowen, and Miyoung Suh

Dietary N-3 Fatty Acid Deficiency and its Reversibility: Effects upon Brain Phospholipids and the Turnover of Docosahexaenoic Acid in the Brain and Blood
William E. Connor, Gregory J. Anderson, and Don S. Lin

The Role of Omega-3 Polyunsaturated Fatty Acids in Retinal Function
Algis J. Vingrys, James A. Armitage, Harrison S. Weisinger, B.V. Bui, Andrew J.Sinclair, and Richard S. Weisinger

Brightness-Discrimination Learning Behavior and Retinal Function Affected by Long-Term _-Linolenic Acid Deficiency in Rat, Harumi Okuyama
Yoichi Fujii, and Atsushi Ikemoto

Part IV. Pathology

Disturbances of Essential Fatty Acid Metabolism in Neural Complications of Diabetes
Joseph Eichberg and Cristinel Mîinea

Docosahexaenoic Acid Therapy for Disorders of Peroxisome Biogenesis
Hugo W. Moser and Gerald V. Raymond

Effects of Fatty Acids and Ketones on Neuronal Excitability: Implications for Epilepsy and its Treatment
Carl E. Stafstrom

Fatty Acid Ethyl Esters: Toxic Nonoxidative Metabolites of Ethanol
Zbigniew M. Szczepiorkowski and Michael Laposata

Part V. Psychiatry and Behavior

Omega-3 Fatty Acids and Psychiatric Disorders: Current Status of the Field
Joseph R. Hibbeln and Norman Salem Jr

Disorders of Phospholipid Metabolism in Schizophrenia, Affective Disorders, and Neurodegenerative Disorders
David F. Horrobin

Eicosapentaenoic Acid: A Potential New Treatment for Schizophrenia?
Malcolm Peet and Shaun Ryles

The Importance of DHA in Optimal Cognitive Function in Rodents
Claus C. Becker and David J. Kyle

The Role of Omega-3 Polyunsaturated Fatty Acids in Body Fluid and Energy Homeostasis
Richard S. Weisinger, James A. Armitage, Peta Burns, Andrew J. Sinclair, Algis J. Vingrys, and Harrison S. Weisinger

PUFA: Mediators for the Nervous, Endocrine, and Immune Systems
Shlomo Yehuda, Sharon Rabinovitz, and David I. Mostofsky