Personalizing Precision Medicine

Kristin Ciriello Pothier started her career sequencing for the Human Genome Project and has subsequently spent more than 20 years in strategy consulting and scientific and clinical research in the healthcare and life sciences industries. She is a leader in precision medicine business strategy and in clinical laboratory innovation, developing product and service strategies and operations worldwide, and is a noted speaker and writer in the healthcare industry. She lives in Massachusetts with her husband and their two lively children.

Acknowledgments vii

Introduction ix

Methodology xiii

About the Author xv

Part 1 The History 1

1 The Right Drug, the Right Patient, the Right Time: Foundations of Precision Medicine 3

2 Decision‐Making Machines: Diagnostics in Precision Medicine 27

3 Precision Medicine around the World: Europe 37

Part 2 The Present 51

4 Our Reality Today: The Patient Journey in Precision Medicine 53

5 Toward the Day We Just Call It “Medicine”: Access to Precision Medicine 65

6 Precision Medicine around the World: Japan 81

7 Shifting Rules: Regulation and Reimbursement in Precision Medicine 89

8 Precision Medicine around the World: Latin America 105

9 Patients as the Poorest Princesses: Supportive Care in Precision Medicine 125

10 Informatics under the Hood: Information in Precision Medicine 135

11 Precision Medicine around the World: India 149

Part 3 The Future 157

12 A Personalized Stomach: Precision Medicine beyond Cancer 159

13 Consumer is King: Consumer Applications of Precision Medicine 181

14 Precision Medicine around the World: The Middle East 197

15 Sci‐Fi Potential: CRISPR as the Next Novel Frontier in Precision Medicine 207

16 Precision Medicine around the World: China 223

17 A New Hope: The Future of Precision Medicine 231

Afterword 241

Index 243