Membrane Transporters in Drug Discovery and Development

Membrane Transporters and Drug Development: Relevance to Pharmacogenomics, Nutrigenomics, Epigenetics, and Systems Biology.- Bioinformatics for Transporter Pharmacogenomics and Systems Biology: Data Integration and Modeling with UML.- Multidrug Resistance: Phylogenetic Characterization of Superfamilies of Secondary Carriers that Include Drug Exporters.- Targeting Drug Transporters – Combining In Silico and In Vitro Approaches to Predict In Vivo.- Methods to Evaluate Transporter Activity in Cancer.- Analysis of Expression of Drug Resistance-Linked ABC Transporters in Cancer Cells by Quantitative RT-PCR.- Fluorescence Studies of Drug Binding and Translocation by Membrane Transporters.- A Model for Transport Studies of the Blood–Brain Barrier.- Genetic Variants in the Vesicular Monoamine Transporter 1 (VMAT1/SLC18A1) and Neuropsychiatric Disorders.- Equilibrium Binding and Transport by Vesicular Acetylcholine Transporter.- ABC Transporters in Ophthalmic Disease.- Imaging of Protein Translocation In Situ in Skeletal Muscle of Living Mice.- Glucose Transporters in Parasitic Protozoa.- NMR Studies of Membrane Proteins.- Site-Directed Mutagenesis in the Study of Membrane Transporters.- Xenopus laevis Oocytes.- Measurement of Intracellular pH.- Measurement of Plasma Membrane Calcium–Calmodulin-Dependent ATPase (PMCA) Activity.- Assessment of the Contribution of the Plasma Membrane Calcium ATPase, PMCA, Calcium Transporter to Synapse Function Using Patch Clamp Electrophysiology and Fast Calcium Imaging.