Adaptation under Stressful Environments through Biological Adjustments and Interventions (eBook)

The book delves into the intricate interplay of stress and adaptive responses, and their multifaceted dynamics influenced by stress type, exposure duration, genetic factors, and lifestyle elements. It unveils the complexity of stress management, unveiling how adaptive strategies evolve in response to stressors. By harnessing scientific breakthroughs in stress response comprehension, the book navigates the path to effective stress mitigation. Through avenues such as pharmacological interventions, dietary adjustments, psychological enhancement, and more, the book advocates for achieving adaptive resilience-a state where the system effectively copes with stress. The text encapsulates an array of stressors, including extreme stress, oxidative stress, and genotoxic stress, dissecting their impact on systemic equilibrium and health. 

The book's focal point rests on adaptive mechanisms that vary with stressor types, while also spotlighting how these mechanisms can be calibrated through pharmacological and alternative means. This is an invaluable resource for understanding, mitigating, and harnessing the power of adaptation in the face of stress-induced challenges.

Dr. Rajkumar Tulsawani is a scientist at the Defence Institute of Physiology and Allied Sciences, Delhi, India, since January 2006. Previously, served at Defence Research and Development Establishment, Gwalior, India; 2000-2006. He obtained his PhD in zoology from Jiwaji University, Gwalior, Madhya Pradesh, India, in 2007 and visited the University of Nebraska Medical Center, Omaha, USA, during 2009-2010 for post-doctoral research work.

Dr. Rajkumar Tulsawani has gained expertise in biomedical sciences and related research areas including pharmacology, toxicology, cellular biology, molecular biology, and analytical techniques. He has research experience in the identification of causes/mechanisms of cyanide and sulfur mustard poisoning (scheduled warfare agents) and the development of therapeutic agents to neutralize their toxic effects. Presently, Dr. Tulsawani's research program focuses on understanding the biological response to hypoxia including chemical and physiological hypoxia and high-altitude maladies, its clinical implication, and therapeutic targeting of hypoxia-responsive pathways. Additionally, he is pursuing research work on understanding the bio-effects and safety of high-energy lasers.

He is a recipient of many awards, notably the DRDO Technology Award, 2023; Gufic Prize, 2019; the Director Award for S&T Coordination, 2019; the Medal of Excellence from Air Force Research Laboratory (AFRL), US DoD, 2018; the DIPAS Laboratory Scientist of the Year, 2016; the CSIR Young Scientist Award from Indian Pharmacology Society, 2005; the Young Scientist Award from Society for Toxicology, 2005; and the Best Performance Award from Defence Research and Development Establishment, Gwalior, India, 2001. He is a recipient of the DST-BOYSCAST fellowship for visiting the University of Nebraska Medical Center, Omaha, USA, in 2009-2010, and served as an external examiner to the universities. He has been associated with three patents (two granted; one at granting stage) and the development of five products; an antidote for cyanide poisoning, a natural performance enhancer, an adaptogen, herbal sanitizer, and herbal sanitizing wipes/towels (for COVID-19 pandemic). He has published over 50 research publications and 2 book chapters, and has been a reviewer of many peer-reviewed journals. He has guided more than 55 scholars (research intern/PhD/Post-doctoral).  

Prof. (Dr.) Divya Vohora is Professor of Pharmacology in the School of Pharmaceutical Education and Research (SPER) at Jamia Hamdard, New Delhi. She has over 24 years of teaching/research experience and has held positions as HoD, Pharmacology; Assistant Dean, Student's Welfare; Director, DODL; andIn-charge of Pharmaceutical Medicine (joint collaborative doctoral program with Sun Pharma).  She has over 200 publications in national and international journals of repute with over 4300 citations and an h-index of 37 as of August 2023. She is also the author/editor of four books published by Elsevier, Springer Nature, and CRC Press, USA. More than 80 research degrees (Master's/PhD/MD) in Pharmacology have been awarded under her supervision.

Prof. Vohora has received prestigious fellowships including fellowship of the National Academy of Medical Sciences (FAMS), India; Indian Pharmacological Society (FIPS); British Pharmacological Society (FBPhS); and Royal Society of Biology, UK (FRSB). She has been listed among the Top 2% of World Scientists by Stanford University study for the whole career and for single year impact in 2020-2021 and 2021-2022.

She is a recipient of several awards including the Dr. B.K. Anand Oration Award and Dr. Vinod Kumar Bhargava Award of the National Academy of Medical Sciences; Distinguished Woman Scientist Award of the Indian Society of Chemists Biologists; Dr. D.N. Prasad Memorial Oration Award of the Indian Council of Medical Research; Pharm Innova Award, Career Award for Young Teachers by AICTE; Fast Track Award for Young Scientists by DST, Government of India; and Chandra Kanta Dandiya Prize in Pharmacology.

She is a member of the International Advisory Group of the British Pharmacological Society, UK, and is an expert member for research grants submitted to the National Science Centre, Poland, and La Caixa Foundation, Spain.

She has worked as a PI on several research grants funded by AICTE, ICMR, UGC, CSIR, and DST, Government of India. Her major areas of research interest are neuropharmacology particularly epilepsy, and neurodegenerative diseases including Alzheimer's disease and associated comorbidities particularly secondary osteoporosis.

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The book delves into the intricate interplay of stress and adaptive responses, and their multifaceted dynamics influenced by stress type, exposure duration, genetic factors, and lifestyle elements. It unveils the complexity of stress management, unveiling how adaptive strategies evolve in response to stressors. By harnessing scientific breakthroughs in stress response comprehension, the book navigates the path to effective stress mitigation. Through avenues such as pharmacological interventions, dietary adjustments, psychological enhancement, and more, the book advocates for achieving adaptive resilience-a state where the system effectively copes with stress. The text encapsulates an array of stressors, including extreme stress, oxidative stress, and genotoxic stress, dissecting their impact on systemic equilibrium and health. The book's focal point rests on adaptive mechanisms that vary with stressor types, while also spotlighting how these mechanisms can be calibrated through pharmacological and alternative means. This is an invaluable resource for understanding, mitigating, and harnessing the power of adaptation in the face of stress-induced challenges.