Epistemology of the Cell: A Systems Perspective on Biological Knowledge

EDWARD R. DOUGHERTY , PhD, is Director of the Genomic Signal Processing Laboratory at Texas A&M University, where he holds the Robert M. Kennedy '26 Chair and is Professor in the Department of Electrical and Computer Engineering. He is also co-Director of the Computational Biology Division at the Translational Genomics Research Institute as well as Adjunct Professor in the Department of Bioinformatics and Computational Biology, M. D. Anderson Cancer Center at the University of Texas. Dr. Dougherty has published more than 300 peer-reviewed journal articles and book chapters. MICHAEL L. BITTNER , PhD, is co-Director and Senior Investigator at the Computational Biology Division at the Translational Genomics Research Institute. Previously, he was associate investigator in the Cancer Genetics Branch of the National Human Genome Research Institute at the National Institutes of Health. Dr. Bittner holds a dozen patents and has published more than 100 articles.

Preface ix Acknowledgments xi 1. Science and Knowledge 1 2. Causality and the Three Pillars of Aristotelian Science 11 3. Scientific Knowledge 35 4. Cells and Factories 59 5. Translational Science 85 6. Stochastic Validation: Classifi ers 97 7. Stochastic Validation: Networks 129 8. Sola Fides 147 9. Model-based Experimentation in Biology 169 References 189 Index 197 IEEE Press Series on Biomedical Engineering 203