Biomedical Micro- and Nanorobots in Disease Treatment

Chun Mao is Professor and Deputy Director at National and Local Joint Engineering Research Center of Biomedical Functional Materials, and he works in School of Chemistry and Materials Science, Nanjing Normal University, China. His research interests include biomedical functional materials, micro/nanoscience and technology, and the diagnosis and treatment of diseases.Mimi Wan obtained her Ph.D. in the Department of Chemistry at Nanjing University, China, in 2015. Currently she is a researcher at Jiangsu Key Laboratory of Biofunctional Materials, at Nanjing Normal University, China. In recent years, she has been engaged in the construction of biomedical functional materials (including mesoporous materials, micro/nanomotors, etc.) and applied them to the treatment of blood-related diseases.

INTRODUCTION
Origin of Biomedical Micro- and Nanorobot
A Long Journey
Moment of Glory
Three Laws
Main Content of this Book

DEFINITION AND CLASSIFICATION
Definition
Classification

DESIGN AND PREPARATION
Substrate Selection
Driving System

CHARACTERIZATION
Motion Characterization
In Vivo Tracking Technologies

BIOSAFETY
Biosafety of Micro- and Nanorobot Substrate
Biosafety of Driving System of Micro- and Nanorobots
Biosafety of Autonomous Motion Behavior of Micro- and Nanorobots
Biosafety Evaluation Methods for Micro- and Nanorobots

AUTONOMOUS MOTION BEHAVIOR
Autonomous Motion Mechanism
Trend Behavior Mechanism
Motion Control

FUNCTIONS
Moving in Complex Physiological Environment
Loading Power Source, Drug or Imaging Agent
Targeting Specific Cells or Physiological Tissues
Promoting Cell Uptake and Improving Tissue Permeability
Imaging Capability
Information Interaction and Intelligent Decision
Diagnosis and Treatment of Disease

FOR CARDIOVASCULAR DISEASE TREATMENT
Thrombus
Atherosclerosis
Cerebral Apoplexy

FOR CANCER TREATMENT
Cancer Diagnosis
Targeting and Delivery
Treatment of Different Cancer Species
Treatment Mechanism
Theranostics

FOR OTHER DISEASES TREATMENT
Ophthalmic Disease
Orthopedic Diseases
Gastrointestinal Diseases
Neurological Diseases
Bacterial Infection
Blood Heavy Metal Poisoning

FUTURE DEVELOPMENT TREND
Biosafety of Micro- and Nanorobots
New Materials and Technologies of Micro- and Nanorobots
Intelligent Micro- and Nanorobots
New Treatment Mode
New Detection Technology for Micro- and Nanorobots
Outlook and Future Challenges