Molecular Pathology in Drug Discovery and Development (eBook)

J. Suso Platero is Director of Oncology Biomarkers at Centocor. Formerly, he was associate director of molecular pathology at Bristol-Myers Squibb. Dr. Platero has more than ten years of experience in the discovery, development, and validation of assays for clinical purposes.

1. Introduction to Molecular Pathology and Drug Development (Franz Fogt, University of Pennsylvania and J. Suso Platero).

2. Molecular Pathology in early drug discovery (Matt Lorenzi, Rolf Ryseck, Brent Rupnow and Ricardo Attar).

3. Molecular Pathology and transcriptional profiling in early drug development (Cornelia Liedtke, Lajos Pusztai and W. Fraser Symmans).

4. Nonclinical Safety Assessment (Richard A. Westhouse).

5. Toxicogenomics in Drug Development (Wayne Buck and Eric A. G. Blomme).

6. Molecular Pathology as a way to find the right dose for the drug (F. Rojo, A. Rovira, S. Serrano and J. Albanell).

7. Molecular Pathology in Life Cycle Management in Drug Development (David Berman).

8. Molecular Pathology and Molecular Therapy (Hewei Li).

9. Contract Research Organizations and Molecular Pathology in drug development (Frank Lynch and Steve Bernstein).

10. Moving to a Quantification of Molecular Pathology: Colorimetric Immunohistochemistry (Raphael Marcelpoil).

11. AQUA Technology and Molecular Pathology (Mark Gustavson, Marisa Dolled-Filhart, Jason Christiansen, Robert Pinard1).

"Molecular Pathology in Drug Discovery and Development is a well-written book that provides both an overview of how biomarkers may be developed and detailed explanations of how to measure and analyze said biomarkers." (The Yale Journal of Biology and Medicine, March 2010)