Introduction to Pharmaceutical Formulation (eBook)
200 Seiten
Elsevier Science (Verlag)
978-1-4831-3853-4 (ISBN)
The book begins with a background on pharmaceutical formulation, describing manufactured and official formulations, important criteria for a formulation, and technical advances in pharmacy during the post-war period. This is followed by separate chapters on diluents, solvents, and liquid vehicles; thickeners and binders; the chemistry and pharmacology of surface-active agents; and colors, flavors, and preservatives. Subsequent chapters cover solid, liquid, and paste formulations; controlled drug release; the stability of formulations; the importance of the container of the formulation; and large-scale manufacturing of formulated products.
This book is intended primarily for students of pharmacy. It is not a textbook of practical or theoretical pharmaceutics but should be read in conjunction with other books on these subjects.
An Introduction to Pharmaceutical Formulation describes the various forms in which drugs may be supplied to doctors, patients, and veterinary surgeons. An account is given of the materials which may be added to drugs in order to provide formulated products, and of the methods by which formulations are assessed. The book begins with a background on pharmaceutical formulation, describing manufactured and official formulations, important criteria for a formulation, and technical advances in pharmacy during the post-war period. This is followed by separate chapters on diluents, solvents, and liquid vehicles; thickeners and binders; the chemistry and pharmacology of surface-active agents; and colors, flavors, and preservatives. Subsequent chapters cover solid, liquid, and paste formulations; controlled drug release; the stability of formulations; the importance of the container of the formulation; and large-scale manufacturing of formulated products. This book is intended primarily for students of pharmacy. It is not a textbook of practical or theoretical pharmaceutics but should be read in conjunction with other books on these subjects.
Front Cover 1
An Introduction to Pharmaceutical Formulation 4
Copyright Page 5
Table of Contents 6
FOREWORD 8
CHAPTER 1. BACKGROUND 10
The Manufactured Formulation 12
The Official Formulation 15
Some Important Criteria 16
Recent Advances 19
Recommended Further Reading 23
CHAPTER 2. DILUENTS, SOLVENTS AND LIQUID VEHICLES 24
Powder Diluents 26
Solvents and Liquid Vehicles 28
Group A: Water-miscible liquids 29
Group B: Water-immiscible liquids 34
Recommended Further Reading 38
CHAPTER 3. THICKENERS AND BINDERS FATS AND WAXES
Thickeners and Binders 39
Group A: Organic 41
Group B: Inorganic 48
Fats and Waxes 50
Recommended Further Reading 56
CHAPTER 4. SURFACE-ACTIVE AGENTS 57
Chemistry 58
Pharmacology 59
CHAPTER 5. COLOURS, FLAVOURS AND PRESERVATIVES 70
Colours 70
Flavours 76
Preservatives 78
Recommended Further Reading 89
CHAPTER 6. SOLID FORMULATIONS 90
Group A: Bulk or Multidose 92
Effect of drug and process on formulation 109
Modifications to tablets 112
Pharmacopoeial control 117
Unofficial tests or standards 118
CHAPTER 7. LIQUID FORMULATIONS 126
Oral 127
Parenteral 131
Topical 138
Body Cavities 140
Recommended Further Reading 145
CHAPTER 8. PASTE FORMULATIONS 146
A. Non-emulsified 147
B. Emulsified Creams 151
Recommended Further Reading 154
CHAPTER 9. THE CONTROL OF DRUG RELEASE 155
The Need for Control 155
Methods of Control 157
Routes of Administration 160
Problems in the Development of a Controlled-release Formulation 164
Recommended Further Reading 166
CHAPTER 10. STABILITY 167
General 167
Types of Instability and their Effect 168
Stability Tests 170
Scheme of Testing 172
Stabilization 177
Assignment of Storage Life 178
Recommended Further Reading 178
CHAPTER 11. CONTAINERS 180
Protection of Contents 181
Convenience in Administration 184
Appearance and Identification 186
Pharmacopoeial Control 187
Recommended Further Reading 187
CHAPTER 12. PROCESS ESTABLISHMENT 188
Equipment 188
Rate of Output 195
Personnel 196
INDEX 200
Erscheint lt. Verlag | 22.10.2013 |
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Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Gesundheitsfachberufe |
Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
Naturwissenschaften ► Chemie | |
Technik | |
ISBN-10 | 1-4831-3853-4 / 1483138534 |
ISBN-13 | 978-1-4831-3853-4 / 9781483138534 |
Haben Sie eine Frage zum Produkt? |
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