Handbook of Genetic Communicative Disorders (eBook)

Front Cover 1
The Handbook of Genetic Communicative Disorders 2
Copyright Page 5
Contents 6
Foreword 14
Contributors 16
Preface 18
Chapter I. Introduction 22
I. Some Background 22
II. What Is the Problem? 24
III. Some Language 26
IV. Some Information 29
Chapter 2. Delineation of Genetic Components of Communicative Disorders 32
I. Historical Aspects 33
II. Genetic Inheritance Patterns 35
III. Identification of Genetic Components 40
IV. Identification of Loci and Genes 42
V. Medical Significance 47
Chapter 3. Prenatal and Postnatal Craniofacial Development 52
I. Phylogenetic Aspects and Embryology 52
II. Postnatal Craniofacial Growth and Development 68
III. Functions of the Human Craniofacial Complex 84
Chapter 4. Morphogenesis and Genetics of Inner Ear Development and Malformation 90
I. Introduction 91
II. Morphogenesis of the Inner Ear 91
III. Genetic Patterning of Inner Ear Development 98
Chapter 5. Genetic Deafness 110
I. Introduction 110
II. Nosology 112
III. Syndromic Hearing Impairment 114
Chapter 6. Genetic Language Disorders 134
I. Specific Language Impairment 135
II. The Genetics of Specific Reading Disability 139
III. Conclusions 144
Chapter 7. Genetics in Craniofacial Disorders and Clefting: Then and Now 150
I. The Genetics of Clefting: Its Evolution over the Past 30 Years 151
II. How Might Mutant Genes Cause Cleft Lip, Cleft Palate, and Craniofacial Anomalies? 154
III. Syndromes of Clefting 155
IV. Sequences and Associations 159
V. When to Be Suspicious 160
VI. The Predictive Power of Understanding Causation 161
VII. Integration of Genetics into the Interdisciplinary Team 163
VIII. Syndromes Commonly Seen in Cleft Palate Centers 164
IX. Does It Really Make a Difference? 166
X. Has There Been an Effect on Research? 169
XL Conclusion 169
Chapter 8. Stuttering and Genetics: Our Past and Our Future 172
I. Introduction 173
II. Stuttering and Genetics: An Abridged Historical Timeline 173
III. Gene Finding: The "Today" and "Tomorrow" of Stuttering Research 183
IV. The Human Face of the Molecular Genetics Revolution 189
V. Concluding Remarks 192
Chapter 9. Concepts in Behavioral Genetics and their Application to Developmental and Learning Disorders 196
I. Introduction to the Basic Model of Human Behavioral Genetics 199
II. Molecular Work and Human Behavioral Genetics 211
III. Toward the Future 213
Chapter 10. Genetic Privacy and Ethical, Legal, and Social Issues 220
I. Genetic Testing 221
II. Genetic Discrimination 222
III. Genetic Privacy 225
IV. Conclusion 230
Chapter 11. Treatment and Prevention 234
I. Introduction 234
II. Treatment 235
III. Prevention 239
Bibliography 244
Author Index 268
Subject Index 282