Pulmonary Endothelium (eBook)

Norbert Voelkel and Sharon Rounds are the authors of The Pulmonary Endothelium: Function in Health and Disease, published by Wiley.

The Pulmonary Endothelium 3
Contents 9
List of Contributors 13
Introduction 19
SECTION I: NORMAL PULMONARY ENDOTHELIUM. STRUCTURE, FUNCTION, CELL BIOLOGY 23
1: Development of the Pulmonary Endothelium in Development of the Pulmonary Circulation: Vasculogenesis and Angiogenesis 25
2: Anatomy of the Pulmonary Endothelium 47
3: Cadherins and Connexins in Pulmonary Endothelial Function 55
4: Pulmonary Endothelial Cell Interactions with the Extracellular Matrix 73
5: Pulmonary Endothelial Cell Calcium Signaling and Regulation of Lung Vascular Barrier Function 95
6: Pulmonary Endothelium and Nitric Oxide 111
7: Pulmonary Endothelial Cell Surface Metabolic Functions 127
8: Cell Biology of Lung Endothelial Permeability 135
9: Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels 151
10: Pulmonary Endothelial Interactions with Leukocytes and Platelets 165
11: Mesenchymal–Endothelial Interactions in the Control of Angiogenic, Inflammatory, and Fibrotic Responses in the Pulmonary Circulation 189
12: Pulmonary Endothelium and Vasomotor Control 207
13: Pulmonary Endothelial Progenitor Cells 225
14: Bronchial Vasculature: The Other Pulmonary Circulation 239
15: Mapping Protein Expression on Pulmonary Vascular Endothelium 251
SECTION II: MECHANISMS AND CONSEQUENCES OF PULMONARY ENDOTHELIAL CELL INJURY 263
16: Pulmonary Endothelial Cell Death: Implications for Lung Disease Pathogenesis 265
17: Oxidant-Mediated Signaling and Injury in Pulmonary Endothelium 283
18: Hypoxia and the Pulmonary Endothelium 309
19: Viral Infection and Pulmonary Endothelial Cells 325
20: Effects of Pressure and Flow on the Pulmonary Endothelium 331
21: Therapeutic Strategies to Limit Lung Endothelial Cell Permeability 359
22: Targeted Delivery of Biotherapeutics to the Pulmonary Endothelium 377
SECTION III:PULMONARY ENDOTHELIUM IN DISEASE 401
23: Endothelial Regulation of the Pulmonary Circulation in the Fetus and Newborn 403
24: Genetic Insights into Endothelial Barrier Regulation in the Acutely Inflamed Lung 421
25: Interactions of Pulmonary Endothelial Cells with Immune Cells and Platelets: Implications for Disease Pathogenesis 439
26: Role of the Endothelium in Emphysema: Emphysema – A Lung Microvascular Disease 459
27: Pulmonary Endothelium and Pulmonary Hypertension 471
28: Collagen Vascular Diseases and Pulmonary Endothelium 483
29: Pulmonary Endothelium in Thromboembolism 493
30: Pulmonary Endothelium and Malignancies 507
Epilogue 513
Index 517