Annual Reports in Medicinal Chemistry (eBook)

Cover 1
DEDICATION 5
CONTENTS 7
CONTRIBUTORS 11
PREFACE 13
Central Nervous System Diseases 14
Attention Deficit Hyperactivity Disorder: Pathophysiology and Design of New Treatments 16
Ionotropic GABA Receptors as Therapeutic Targets for Memory and Sleep Disorders 26
Melatonin Agonists for the Treatment of Sleep Disorders and Major Depression 38
Cardiovascular and Metabolic Diseases 52
Recent Advances in Therapeutic Approaches to Type 2 Diabetes 54
Recent Progress in Histamine H3 Receptor Chemistry 70
Anti-Resorptive and Anabolic Bone Agents 80
Inhibition of the Cysteine Protease Cathepsin K (EC 3.4.22.38) 92
Nonpeptide Gonadotropin Releasing Hormone Antagonists 112
Inflamatory, Pulmonary, and Gastrointestinal Diseases 8
Bradykinin B2 Receptor Antagonists for the Treatment of Pain 126
Selective Cyclooxygenase-2 Inhibitors 138
The Discovery of Small Molecule C5a Antagonists 152
CCR1 Antagonists 162
Cancer and Infectious Diseases 172
Recent Advances in Antimetabolite Cancer Chemotherapies 174
Mitotic Kinesin Inhibitors as Novel Anti-cancer Agents 186
Recent Advances in Medicinal Chemistry of Histone Deacetylase Inhibitors 198
Therapeutic Opportunities for the Treatment of Biofilm-Associated Infections 210
Biowarfare Pathogens. Is the Research Flavor Different Than That of Clinically Relevant Pathogens? 224
HCV Anti-viral Agents 236
Topics in Biology 252
Pleiotropic Effects of Statins 254
Comparative Protein Structure Modeling and its Applications to Drug Discovery 272
Topics in Drug Design and Discovery 290
Drug Transporters and Their Role in Tissue Distribution 292
The Hit-to-Lead Process in Drug Discovery 306
Prodrug Strategies in the Design of Nucleoside and Nucleotide Antiviral Therapeutics 318
Pre-Clinical Assessment of Drug-Induced QT Interval Prolongation. Current Issues and Impact on Drug Discovery 336
Trends and Perspectives 348
To Market, To Market„2003 350
COMPOUND NAME, CODE NUMBER AND SUBJECT INDEX, VOL. 39 382
CUMULATIVE CHAPTER TITLES KEYWORD INDEX, VOL. 1–39 388
CUMULATIVE NCE INTRODUCTION INDEX, 1983–2003 406
CUMULATIVE NCE INTRODUCTION INDEX, 1983–2003 (BY INDICATION) 424